noise is the same as a regular case. the 2 little spot cool fans are near silent and also not really necessary at all, not to mention they dont do much just a touch of circulation. so the only real noise is coming from the cpu fan. its what you would expect. my gfx card fans only come on when needed....and the power supply is what it is.
all in all it might even be a bit quieter than a normal case considering theres no real case fans.
as for the speakers....theyre up on the window sill above the desk for now....and behind me at the other end of the room. im not sure what my final placement is going to be for those yet....ill probably wall mount them all. i do most of my music stuff at night so i mainly use headphones for that. besides...ive been using this kind of a set up for so long that i can compensate accordingly for poor room acoustics (for the most part....thats what the mastering engineer is for anyway