Once in a while I sample and while doing that I hear some noise or distorsion that I cant correct with my EQ (high shelf) treble adjusting. For example, a drum loop that consists of small ms silences between the hi-hats, the whole clip consists of small clips and noise, can I remove those that even can be heard during a hi-hat? Omg this question is simple but I managed to make it complicated, sorry. I am looking for a reliable VST for this, preferably not a freeware buggy vst, but a commercial product that is stable and that I can use long-term.

I googled but it would be nice to have some personal tips

You can do this in Audacity, which is free, but it just takes time and patience. The one great feature is the Show Clipping selection. Then you can select the individual peaks that are causing you trouble and fix. It also has a very nice Noise reduction feature. The problem with a loop is you're going to have to find a point in the loop where it's just the noise. Drumloops are hard because they can have reverb tails on them, and you can actually make them worse.
But, with all the free demo loops on all these sound websites, you can grab something fresh, but I know how it is when you just have to have THAT SOUND.
Good luck.

You're talking about the iZotope RX2. Swiss Army knife of noise reduction, click repair, harmonic surgery, you name it. http://www.izotope.com/products/audio/rx/

I have it and use it (the Advanced version) but the regular version has features and quality in spades.

If you need to remove a lot of noise, it's usually better to run the audio file twice, with less NR, than to try to eliminate it all in one go.

I don't think you'd ever regret getting RX2, but be aware that there's a bit of a learning curve to get the best out of it.

Good luck!

/Joachim

Elevayta's Klean Boy (what's up with that name?) is probably the easiest noise reduction with very, very good results. For the price this is a no brainer purchase.

For more control Voxengo Redunoise is a top choice. It's more complex and requires some study to get the best results. I like its envelopes which allow to zoom in on specific regions without affecting others. Sadly, Klean Boy does not allow this.

I use both, depending on application. In the past I have also used other noise reduction plugins (Virtos and the one which comes in Samplitude) which are not as good as the two above. No experience with the Izotope one (or the one made by Bias).

I use ReaFir in Reaper. I get pretty good results.

+1

I typically find myself using RX2 in lots of capacities these days. On this track:

http://lightsfadelow.com/track/small

The singer moved around a lot and I found all sorts of interesting sounds that needed spectral repair--her jewelry, mouth noises, and the sound of her shaking the lyrics sheet in her hand. I also used the de-noiser on the whole vocal. And it sounds pristine in the final mix (in my opinion).

Just found cause to use this. Worked a treat for the purpose of removing some vinyl noise from a quite vinyl choir.

who wants to remove vinyl noise?

voxengo redunoise is my favorite broadband NR plugin. It Is insanely flexible. For simpler applications, like when there is no wanted signal present, you can generally get by with a simple gate or expander. A multiband gate or expander is obviously going to give you a wider range of results.

Possibly the single most important thing to know about noise reduction.