I got this synth for half price during the beta period, but honestly, it's well worth the full asking price! If you're looking for virtual analog, this is THE soft synth. Growling, wobbling, screaming, soaring, crisp, warm, fat, creamy, fuzzy, smooth and all the other buzzwords surrounding positive sound characteristics probably apply to what's drifting out of this thing.
The gui has been debated since the release, with its fairly large size and angled viewpoint. Of course, if you're still running on 1024x768 or lower it takes up your screen, and some might have difficulties with reading what's on the mod knobs. But the good admiral has provided the option of drop-downs instead of the mod knobs and made it skinnable, and some of the skins are gorgeous!
To obtain the lovely sound, it consumes a bit of cpu, but nothing dramatic. On my fairly basic dual core laptop I can run a fair amount of instances in normal quality before going into red alert.
The number of presets are growing in the Poly-Ana patch exchange (and some of them are awesome) but whipping up your own is also easy and fun!
Also worth mentioning is that I'm running most of my music software in linux through Wine, and Poly-Ana gives me no problem here, unlike some other synths. It has never crashed, and when I needed a new serial for the latest version, AQ replied with a new one within a very short time.