Same problem for me with Effectrix. When the Effectrix is selected (the focus is on Effectrix) the playback shortcut SPACEBAR does not work. You have to select the DAW (change the focus to DAW) to get the SPACEBAR to work.
So what cyphersuit ment here, was that the SPACEBAR is not working with WOW. I have this problem with Sleepy-Records plugins and Effectrix. I guess all the Sugar Bytes VSTs have the same issue in Studio One? Haven't tested others than Effectrix atm, because I don't own any.. yet.