Seems like Crossfade Loopsynth kills MU.LAB 1.0 dead when you try to open/change .fxp files.
[wild conjecture]
Not sure if I'm making this up but it seems to be related to mouse movement immediately after you load a program. Also, the chance of the bug occuring seems to increase over time as you flip back and forth between .fxp in a single instance of Loopsynth.
[/wild conjecture]
Mac Mini intel, OSX 10.4.8
Marco
