I thought I had it nailed because the crackles wasn't audible when I tested Virus Control in Renoise 2.8 64-bit version, so I figured it was because I was using a 32-bit Cubase on a 64-bit OS. But last night I discovered that the problem also appeared in Renoise, so I decided to submit a support-request to Access Music. They've replied very fast (incredibly fast actually), and I've got a few more things to check, but I would really like to hear if anyone has had any similar issues, and what you've done to fix it?
For the record, I've tested various setups, including increasing the buffer on my Firewire 410, choosing the Virus as audio-interface with highest possible buffer-setting and unplugging all other USB devices but the Virus. All with no luck.
Running the Virus "standalone" doesn't produce the problem.
Here's an example of the crackled sound: http://www.sendspace.com/file/6bmlxj
It's just a minor chord with automation of the filter opening and closing.
I just love those deep lush dubby sounds