There is actually no "behind the scenes" interaction, but even though the modules chain looks similar to traditional amp modeling (it's on purpose - it would have been difficult to get started otherwise), you may want to think about it differently. The destruction module is not a static waveshaper, and its quite complex behavior may include non-linearities that could be associated with a cabinet too. You can simulate many types of amp sounds, but you may want to start forgetting how traditional sims do it and to get the best out of the plug-inThe manual says that too, however I don't understand why or how - is there some underlying function, perhaps some trade-secret you do not want to reveal? I really struggle to understand in which way the destruction module affects the post filtering if these filters do not include any signal-depended function.
.Once you have discovered the plug-in and setup your own virtual amps, you will probably just close the full-edit mode and move the "easy' knobs to adjust the amp settings. But well, everyone is different: some customers only use the easy mode with presets, some keep tweaking the plug-in in details.b.t.w.: I find the easy view as it is almost useless - I almost always use the fully expanded edit mode instead.
That's probably even more difficult to use if not an expert in acoustics / physics!