I really believe that this is number one challenge for Reason's popularity. Propellerhead should concentrate on upgrading the GUI size before anything else.
Currently I'm ok, although will avoid using the old devices, but my monitor is 4 years old and in one year I will buy another monitor. It's mostly will be 32" to 34" as I measured my space and can't fit bigger one.
So, it's logical to say from now that I will use what I can see