I'm guessing the OP has vision problems, that's too bad. Maybe some glasses might help
Anyhow my only issue with running Reason at 4k or beyond is that it lags.
I have a small cheap monitor with a max resolution of 1280x720 that works just fine for reason when I absolutely have to use it. If i use my thunderbolt2 4k display though it lags pretty bad.
I don't have this issue with Bitwig studio though.