I have one:
The mouse wheel scroll behaviour changed in 10.5 in every selector windows (those that open when you want so select an insert plugin). For every mouse wheel "click" it now only scrolls one line of text instead of like three as before or in any other part of Cubase where you scroll lists like media bay or plugin manager. This makes browsing the plugin list soooo slow and painful as it takes so much finger movements, I'm pretty sure I'll get index finger RSI soon.
Yeah, I know I can search, and the search is great, but that only helps if I know what plugin I want.
And to remove an insert I usually clicked the arrow and with one mouse wheel movement I was at the top and could select "no effect". Now it's a PITA.
That is the only thing I really hate about the update so far...