I am once again asking you for out-there, innovative software instruments and effects

[SparkySpark]

Sugar Bytes stuff.
MMorph.
MSpectralDelay.
2gether Audio G8tor.
Good ol' Glitch (32 bit version).
And by all means, sampling voice and household items! (and combining them with the Melda stuff mentioned above)

[cyrb]

I don't think you can get much more 'out there' than Synplant. https://soniccharge.com/synplant

[SparkySpark]

I don't think you can get much more 'out there' than Synplant. https://soniccharge.com/synplant

Very true!

[nordickvr]

has giorgio sancristoforo allready been mentioned ?

http://www.giorgiosancristoforo.net/softwares/

quite unique and special soundsculpting toys imho
my favorite is gleetchlabX
imho quite bonkers

oh, and i see he has just about to put out a new one: substantia

Thanks!
You just made me discovering this dev.
Many gems over there.

[rj0]

Out there. Hmm.

Probably the most "out there" sounds I've heard were with a convolution reverb, an IR set like Spirit Canyon Audio's (company folded, I believe), and just about any sound source (synth, etc.). With the right IR set, those sounds can get pretty wild.

[dandezebra]

I have been trying to get the Spirit Canyon IR sets for years!

[Dirtgrain]

Ya, I use Trash 2 convolution a lot, although I have yet to try using third party IRs with it. Melda's MConvolutionEZ (free) has some nice IRs in its "sound design" presets.

[psynical]

this guys instruments are about as out there as they come...

http://www.everythingturns.com/ET-V2/collective-8.html

[JO512]

The oscilloscope music plugins by Soundemote are incredible!

https://www.soundemote.com/plugins

I especially like Radar Generator and Nyquist Generator. There is nothing out there remotely like them. They aren't ambient soundscape generators like most of what has been posted in this thread, but they can certainly make some sounds that would layer nicely into such soundscapes! These synths create some very rich and complex timbres using an approach quite unlike the usual saw, square, triangle, and sine oscillators.

These simply don't get enough attention. I'd love to see these guys succeed. I want to hear what else they come up with!

[V0RT3X]

2C audio kaleidoscope.
Fed by something like u-he bazille.

This

and you might also want to check out Metasynth.
http://uisoftware.com/MetaSynth/

[andi75]

You can get some crazy stuff from structural morphing
http://www.zynaptiq.com/morph
Just demo'd it and still not sure if it fits the bill for me though

[Spring Goose]

Sonic Charge's Microtonic drum synth & sequencer has 1,000s of v weird drum patterns to play with - free.

The Microtonic Patternarium is certainly free, but Microtonic itself is $99 plus vat.

That (patternarium) is awesome!

A.A.S. Objeq Delay is a good one for me, though probably not as crazy as some of the recommendations in this thread.

[Spring Goose]

Pretty much everything by Sugar Bytes. Aparillo has already been mentioned; see also Obscurium, which is definitely unique. There's nothing else out there like it, especially when you use it to drive VST notes & parameters.

My gripe with Obscorium is that it isn't possible to also automate the VST parameters in my host (Reason) or is it?

[fisherKing]

+1 for sugar bytes aparillo. weird, and fun...

[Smapti]

Pretty much everything by Sugar Bytes. Aparillo has already been mentioned; see also Obscurium, which is definitely unique. There's nothing else out there like it, especially when you use it to drive VST notes & parameters.

My gripe with Obscorium is that it isn't possible to also automate the VST parameters in my host (Reason) or is it?

Yeah, you can indirectly automate the VST parameters by modulating Obscurium's parameters, but I don't think you can directly automate them. For me this isn't a problem since the point is to let Obscurium automate those parameters itself. If you need direct access to the VST parameters in a particular situation then you probably don't want to use Obscurium.