It's not really an option for most people, yet. I use Linux every day and have been for decades and I still hate it for audio.
To work through some of the crap I've switched one of my work machines to Linux and I do some simple audio/video editing and live production. I'm going to do all of that in Linux using only natively compiled Linux plugins and apps that are painless to install. For that though, I don't care at all about things like latency. There's no performance, per se, and I don't even monitor the audio while recording.
Wine is great, wine is still a pig. Things run, but no they don't. You can smooth fonts, but wait, it's not working correctly everywhere and there are 47 different and conflicting sets of instructions to get that working.
Linux on the desktop isn't even that hard anymore. X just works, apps and updates are easy. I had my work machine up, from scratch, on a brand new laptop in less time than it would have taken to configure and update Windows. The Windows that the machine came with never even saw the light of day. First boot was into the BIOS so I could tell it to boot from the USB install disk on the second boot. I didn't have to hunt down a single driver, it all works. It even works with my Kontrol 1 which is no longer supported on Windows 10. Just plug it in, and there it is. Ethernet dongle just works and I didn't order anything special, just what was cheap on Amazon.
Reaper works great in Linux using the standard Linux distribution. Everything just works. It's just when you start looking at Wine and ASIO and multi-input sound cards, and controllers for those sound cards and on and on it just gets messy quickly and most people don't have the patience for it. I do nerdy tech things on the daily and I get fed up with it.
Maybe I'll change my mind later this year after doing some audio/video work on the new daily driver.
