For me I'll start off with my basic lead tone settings on tube amps (my jumping off point anyhow, then from there it's about the amp and it's characteristics)
I like to turn the amps drive knob up to about 3 or 4 to start (then I season to taste), roll way back on the master (for starting purposes anyhow) then for tone I generally put the bass up to about 7, the mids between about 4 and 6 the treble about 6-8 and presence if there is one a little higher than the what the treble is set for.
This gives a good "crunch plus" tone if you will. Hitting the input with some overdrive is where it all happens. So something like the Boss turbo od, or an eq pedal always works well. The idea is to get the ax7's (pre-amp tubes) excited, though I found I can better achieve the results I like with less hiss by using the EMG PA2 onboard pre-amps (the afterburner would work even better). However not a lot of drive on an overdrive and the gain fairly low (if using a pedal), just enough to liven up the tone some...and if any tone control is used I might push it to the treble side a little, rarely towards the bass.
With this set-up I can get the amp to be "on the edge" as I like to think of it. Really active, open sound with lot's of sustain and ready to scream. It works nice for me with rolling on and off the volume on the guitar (one of the reasons I prefer the pre-amps on the guitar), but switch off the overdrive you're using and you got a nice rhythm tone that still has that little extra "sizzle" and sustain for squeals and such...hit the overdrive and it jumps out at you without being a wall of noise...
Next????

