Recommendation on motherboard and audio interface

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Type of music I do :
I mainly produce music using virtual instruments using a midi keyboard. Rarely some vocal recordings.

My set up currently:
I am currently using Focusrite Scarlett 2i4 (1st gen) and motherboard- Gigabyte Intel LGA 20113 X99 4way SLI/CrossFireX ATX Motherboards GAX99UD4. I have 32 gigs of RAM.

Need:
Need an upgrade to reduce latency and process more virtual instruments/plugins seamlessly.

Recommendation needed:
Any good recommendation for audio interface. I am looking at Apollo Solo. Would Apollo solo suffice for my need? To get the maximum out of it, I am hearing thunderbolt 3 is the way to go.
My motherboard doesn't support thunderbolt. Do I need to upgrade my motherboard as well? If so, Any good recommendation for motherboard as well?

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I think the general consent here and eslewhere is that the RME interfaces have the best performance/latency.

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vignesh.vijay wrote: Fri Dec 17, 2021 3:28 pm reduce latency
RME.
vignesh.vijay wrote: Fri Dec 17, 2021 3:28 pmmore virtual instruments/plugins
Faster CPU.

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The best performance is RME HDSPe AIO Pro PCIe
viewtopic.php?p=8293709#p8293709

For the new PC, check
viewtopic.php?f=16&t=574244&p=8284100#p8284100

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How would I connect my midi keyboard and mic to RME HDSPe AIO Pro PCIe?
There seems to be no slots available at least from this image below.
https://www-vintageking.com.imgeng.in/m ... pe_aio.jpg

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How big is the latency difference between uad Apollo solo and RME HDSPe AIO Pro PCIe?
Is it even noticable?

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vignesh.vijay wrote: Tue Dec 21, 2021 9:49 am How would I connect my midi keyboard and mic to RME HDSPe AIO Pro PCIe?
There seems to be no slots available at least from this image below.
https://www-vintageking.com.imgeng.in/m ... pe_aio.jpg
With a cable, read the manual
https://www.rme-audio.de/downloads/hdspeaiopro_e.pdf
vignesh.vijay wrote: Tue Dec 21, 2021 9:52 am How big is the latency difference between uad Apollo solo and RME HDSPe AIO Pro PCIe?
Is it even noticable?
HDSPe AIO Pro is the BEST performance of all!
Yes it will be noticeable, the difference against the Apollo USB will be big
and the TB less, maybe they tested in
https://gearspace.com/board/music-compu ... st15205348

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