Ofc the conversation is open because certain things can get trivial to get working and helping each other is always a plus.
I start with my current setup.
Distro: Nobara (based on Fedora)
Compatibility Layer: Soda 9 through Bottles, so i don't have to downgrade my system wine because of the yabridge/wine issue, but i can use a script that use that wineprefix to load my daw/yabridge/win plugins with my linux native daw (reaper)
Melda version: 16.04 i know it's older but it works and i don't need the new manager
Difficulties/issues: The main issue to make it work was the yabridge/wine issue, i'm not an expert linux user, so it took me a while to get it working, and i have to say that chatgpt helped me.
Plugin wise, i still didn't made any intense workload, but everything seems working, unfortunately cpu usage is way higher than windows, that's the only downside i've noticed so far.

