Helix Native

Helix Native is an excellent amp sim from the company that pretty much invented the category. Presets can be shared between Helix Native and Helix hardware, so the hardware can act as an accelerator for your computer system, and you can take the exact sound you used in the studio to a gig. Of course it will need a bit of tweaking for the live system. The GUI is totally resizable, easy to use, and there are many many sonic possibilities. It's set up as a signal path with effects inserted.

Of course there is an inter-ap store where you can buy additional presets and impulses for what seems to me like reasonable prices.

It's not inexpensive, but delivers, especially if you own Helix hardware.