This is, along with Native Instruments' Absynth 5, my favourite virtual instrument.
The synthesis method is quite difficult to understand, but you can quickly get a sound, thanks to the randomize function. You can use your own samples on the three parts of the synth : Hammer, Centre Wave and Masses Wave. Add a little bit of FM, an effect, a filter, press the "Danger" button, multiply the oscillators with different distributions of frequencies, and enjoy the powerful sound of Enzyme.
All parameters are tweakable by LFOs and enveloppes, and the modulation matrix is infinite.
I don't understand why nobody ever rated or reviewed this synth, because it is simply amazing. I tried a lot of VSTIs and was often disappointed by the lack of innovation, but this one is a beast.