TX16Wx is overlooked and underrated, despite being the best software sampler today. And I'm not even talking about the Pro version – the free version can easily compete with commercial products. To my mind, it has everything you need for creative sampling:
The fact that it actually SAMPLES: you don't necessarily have to use samples – you can record your own sounds straight into TX16Wx and start editing them right away.
Great looking GUI (which is also resizable and customizable).
Huge feature list that ensures comprehensive sound design and sample editing possibilities.
Low CPU usage (though it can be quite high if you decide to use extreme quality settings).
TX16Wx doesn't have a 100 GB sample library because it was never intended to. Its purpose is to bring back the joy of sampling. And I believe TX16Wx serves its purpose really well.
Although it is a feature-packed sampler, don't be intimidated and discouraged – you don't need to use all of its features. In fact, thanks to flexible GUI, TX16Wx can be as simple as a sampler can get: just hide the panels that you don't want to use – this way you will have less complex GUI and faster workflow. Also, as always – make sure to read the manual before using it.
Finally, it has active support and the Pro version is very reasonably priced, so if you like using TX16Wx free, I think you should definitely support the developer by purchasing the Pro version.